Is sodium current present in human sinoatrial node cells?
نویسندگان
چکیده
منابع مشابه
Is sodium current present in human sinoatrial node cells?
Pacemaker activity of the sinoatrial node has been studied extensively in various animal species, but is virtually unexplored in man. As such, it is unknown whether the fast sodium current (I(Na)) plays a role in the pacemaker activity of the human sinoatrial node. Recently, we had the unique opportunity to perform patch-clamp experiments on single pacemaker cells isolated from a human sinoatri...
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There is an ongoing debate on the mechanism underlying the pacemaker activity of sinoatrial node (SAN) cells, focusing on the relative importance of the "membrane clock" and the "Ca(2+) clock" in the generation of the small net membrane current that depolarizes the cell towards the action potential threshold. Specifically, the debate centers around the question whether the membrane clock-driven...
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ژورنال
عنوان ژورنال: International Journal of Biological Sciences
سال: 2009
ISSN: 1449-2288
DOI: 10.7150/ijbs.5.201